CMDF
Canadian Medical Discoveries Funds
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New Invesment Advisor
On October 6, 2006, Canadian Medical Discoveries Fund (CMDF) announced the appointment of Jove Investment Management Inc. (“Jove”) as the new Investment Advisor to the Canadian Medical Discoveries Fund.

The new management team has been extremely active in the strategic restructuring of the portfolio to minimize exposure to early stage investments and refocus the portfolio on later stage businesses. With the objective of reducing investment risk and accelerating positive performance, the portfolio has been refined from over 60 investments earlier in 2006 to approximately 35 investments at the end of the year.

Portfolio Realignment
The management team has been harvesting CMDF investments and creating portfolio liquidity in order to:

  • Align the majority of the portfolio with the revised investment objective
  • Free up funds for follow-on investments in promising companies focused on the testing, production and commercialization stages of development
  • Provide liquidity and a significant cash position, enabling the investment management team to take advantage of a changing life science marketplace
The Manager believes that the revamped CMDF portfolio and new investment strategy strongly position the Fund to generate positive returns in the coming months and years.

Investment Objective
The Fund's primary objective is to achieve long-term capital appreciation through investment in eligible Canadian businesses engaged in the health sciences sector, with emphasis on the testing and development, or production and commercialization stages of development. The health sciences sector encompasses a broad range of scientific disciplines and industries that relate to or have an impact on health care including, without limitation, life sciences, biotechnology, diagnostics, medical devices, drug discovery and development, health care delivery services and e-health.
The Fund invests in a variety of product development initiatives as well as businesses with products, technologies or services in different stages of development. Prospective investments by the Fund will be evaluated in terms of a number of criteria, including the commercial potential, management experience, competitive advantage, stage of development, capital requirements, exit opportunities and return profile.

Investment Strategy
To achieve its objective the Fund will:

i. when appropriate investment opportunities arise, invest the capital raised from the sale of Class A Shares in eligible Canadian businesses engaged in the health sciences sector, with emphasis on those businesses involved in the testing and development, or production and commercialization stages of development; and
ii. pending investment in appropriate eligible Canadian businesses, invest the remainder of the capital raised into a combination of high-quality, short-term government and corporate debt obligations and, in particular, equity or equity linked securities of North American biotechnology and health care related companies or debt instruments which generate a return which is linked to the performance of a managed basket of North American biotechnology and health care related companies.
The Manager has retained Jove Investment Management Inc. (“Jove”) as portfolio advisor to the Fund to carry out the investment strategy.

Investment Opportunity
Canada has the third largest biotech industry internationally, which is considered by some to be the fastest growing and most cost-effective for conducting research and development. Canadian biotech companies rank third in generating biotech revenue, about $1.7 billion, behind the United States and the United Kingdom.
The regulatory environment is also expected to become more favourable to companies. The Canadian Biotechnology Advisory Committee, a Government of Canada mandate, recommended to Industry Canada to refining the taxation regime so that it is more responsive to the needs of small enterprises and facilitates the financing of commercialization efforts by small- and medium-sized enterprises.
The Fund recognizes and seeks to capitalize on opportunities that have been or will be created by the enormous commercial potential of the health sciences sector. For 2005, Canadian health expenditures were estimated to be $140 billion or about 9.7% of Canada’s national income gross domestic product (“GDP”). In the United States, health care expenditure were expected to reach US$2.0 trillion or 16.2% of GDP in 2005 . Health care expenditure growth over the past 20 years has never gone below 5%; several of those years experiencing 10% growth on a year over year basis . The Fund believes that several demographic, technological, market, and societal factors will further increase consumption of health science products, services and technologies, leading to an improved investment climate. The primary drivers of this growth are: i) aging demographics; ii) acceleration of technological advancements; and iii) maturation of the biotechnology market.

Identifying Opportunities
The investment criteria used by the Fund to select particular investments will consist primarily of the following:
Management:

  • The Fund will seek to invest in companies where senior management is well qualified and motivated to succeed, or where the technology and product is sound and management can be replaced.
  • Competitive Advantage: The Fund will seek to invest in companies with promising proprietary technologies and/or unique business models which can provide an enduring competitive advantage. Investments in services companies will be considered if significant barriers to entry exist or the business model is sufficiently unique to provide a competitive advantage.
  • Market Opportunity: The Fund will focus on technologies and intellectual property that have the potential to serve the global marketplace. Portfolio Companies should have the potential to grow to at least $300 million in value within 4 years of the time the Fund invests.
  • Return Profile: The Fund will seek to make investments that will provide the Fund with at least a 30% annualized return on investment.
  • Revenue Model: The Fund will focus on companies which have viable business models with realistic plans to achieve profitability.
  • Liquidity and Exit Opportunities: The Fund will focus on companies which have the potential to provide the Fund with more than one exit option. Within a 2 to 4 year time frame, the Fund expects to have a liquid market for its investment or a merger and acquisition liquidity event.
  • Development Stages: The Fund will focus on businesses involved in the Testing and Development, or Production and Commercialization stages of development which have significant potential for growth.
  • Capital Requirements: The Fund will participate in financings where, in the opinion of the Fund, the investment will position the company to reach significant value creating milestones.
  • Follow-on Financing: The Fund will provide additional funding primarily to successful investments which meet predetermined milestones.
  • Portfolio Diversification: The Fund will seek to invest in a broad range of companies involved in the health science sector with the intention of having a balanced portfolio between therapeutic companies and medical device, diagnostic and service companies.

Evaluating Investments
A rigorous evaluation of eligible investment opportunities is performed by CMDF's team of experienced venture capitalists who focus exclusively in the life sciences industry.

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CMDF Net Asset Value
as at 09/18/07: $9.02


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Investment Activity Summary
2006 Divestitures:
$42.5 million
2006 Follow-on
Investments:
$19 million
Q1-Q2 2007
Planned Transactions:
$60+ million